Islet transplantation for the treatment of type 1 diabetes

Alberta STE Report written under contract with the Alberta Health Technologies Decision Process (AHTDP).

This report is an update of the 2008 report on islet transplantation (IT) for Type 1 diabetes (T1DM). Section One of this analysis was intended to describe the profile of T1DM (definition, progression, epidemiology, and population dynamics of affected adults in Alberta, in Canada, and worldwide) and patterns of care for this condition in adults (focusing on recommendations from evidence-based guidelines), as well as to identify potential inequities in health status or care across adult population groups. Social, ethical, and legal issues associated with the provision of IT as a treatment for adults with T1DM were also considered. Section Two of the analysis was to determine, for the treatment of patients with T1DM in Alberta, the potential role of IT compared to whole pancreas transplantation or intensive insulin therapy (IIT). The objective of the economic analysis in Section Three was to estimate the costs and cost effectiveness of IT compared to IIT alone.

Section Authors:

• Section One – Social and System Demographics Analysis Approach: Paula Corabian
• Section Two – Safety and Effects of Islet Transplantation: Bing Guo, Paula Corabian, Christa Harstall
• Section Three – Economic Analysis: Anderson Chuck, Charles Yan
• Information Specialist: Liz Dennett

Related Reports:

• Islet Transplantation for the Treatment of Type 1 Diabetes - An update (2008)
• Islet Cell Transplantation for the Treatment of Non-uremic Type 1 Diabetic Patients with Severe Hypoglycemia (2003)