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The outcome of IHE initiatives is providing better information for developing health policy and best medical practices. IHE disseminates information in many ways. In addition to publications in peer-reviewed journals, IHE produces books and a variety of reports synthesizing information in a particular field.

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Results for: Paula Corabian

Clinical effectiveness and cost-effectiveness of Oncotype DX and Prosigna genetic testing in early-stage breast cancer

May 30, 2019

| Michelle Pollock, Ann Scott, Jennifer Seida, Paula Corabian, Andrew J. Sutton, Mike Paulden, Christopher McCabe, Lisa Tjosvold, Bing Guo

The clinical review and economic evaluation aimed to determine how Oncotype DX and Prosigna can be optimally used to determine which patients with early-stage breast cancer will benefit from adjuvant chemotherapy. This report addresses the following research question: For patients with early-stage (I–III), ER+, HER2?, node-negative or node-positive (one to three nodes) breast…

Adaptive Evolution in Rapid Assessments: A 25-Year Perspective

February 28, 2019

| Paula Corabian, Bing Guo, Carmen Moga, Ann Scott

This article retrospectively examines the evolution of rapid assessments (RAs) produced by the Health Technology Assessment (HTA) Program at the Institute of Health Economics over its 25-year relationship with a single requester, the Alberta Health Ministry (AHM).

Conducting rapid assessments: Lessons from 25 years of good practice

February 20, 2019

| Paula Corabian, Bing Guo, Carmen Moga, Ann Scott

The Health Technology Assessment Program at the Institute of Health Economics has conducted rapid assessments (RAs) since 1993. This information paper draws on this experience and describes the evolution of RA process and products over a 25-year relationship with a single requester to quantify the effects of this partnership on the RAs produced. The aim is to contribute to emergent…

Evidence grading systems used in health technology assessment practice

August 03, 2018

| Paula Corabian, Lisa Tjosvold, Christa Harstall

This study originated from discussions on how to translate research findings into conclusions regarding safety and effectiveness in systematic reviews responding to requests from a provincial mechanism for introducing and diffusing publicly funded healthcare technologies. Its objective is to identify prominent and reliable evidence grading systems used in health technology assessment…

Community paramedicine: Program characteristics and evaluation

September 29, 2017

| Bing Guo, Paula Corabian, Charles Yan, Lisa Tjosvold

This evidence-based report examines expanding the role of paramedics in the community. It summarizes the various types of community paramedicine programs (characteristics, implementation, and funding sources in other jurisdictions) as well as the safety, effectiveness, and economic outcomes of these paramedic programs towards providing patients with alternate, non-emergency health…

Exploratory brief on glucose monitoring technologies

January 26, 2017

| Paula Corabian, Dagmara Chojecki

This report provides a summary of recently published information (January 2015 to present) regarding the glucose monitoring technologies that are commercially available in North America, as well as those that are emerging within the next five years (up to 2021).

Exploratory Brief on Nanomedicine or the Application of Nanotechnology in Human Health Care

March 21, 2012

| Paula Corabian, Dagmara Chojecki, Christa Harstall

This exploratory report provides a summary of some of the published information on the current status of research in and potential future sphere of activity of nanomedicine (Part I) and an inventory of resources on nanotechnology and nanomedicine (Part II). Over the next 5 to 10 years it is expected that the overall impact of nanomedicine will be multifaceted, with significant…

Treatment for convicted adult male sex offenders: an overview of systematic reviews

January 01, 2011

| Paula Corabian, Liz Dennett, Christa Harstall

This article is an overview of systematic reviews reporting on the efficacy/effectiveness of psychotherapy and/or pharmacotherapy interventions delivered within Sex Offender Treatment (SOT) programs to reduce the risk of re-offending in convicted adult male sex offenders. Related Report: Treatment for Convicted Adult Male Sex Offenders

Treatment for Convicted Adult Male Sex Offenders

July 20, 2010

| Paula Corabian, Maria Ospina, Christa Harstall

This health technology assessment report is an overview of systematic reviews reporting on the efficacy/effectiveness of psychotherapy and/or pharmacotherapy interventions delivered within Sex Offender Treatment (SOT) programs to reduce the risk of re-offending in convicted adult male sex offenders. Information Specialist: Liz Dennett

Effectiveness of Organizational Interventions for the Prevention of Workplace Stress

January 13, 2009

| Lisa Bergerman, Paula Corabian, Christa Harstall

The purpose of this report is to advance the area of workplace mental health through a comprehensive synthesis of published research evidence. More specifically, this report examines the evidence on the effectiveness of organizational-level interventions for the prevention of stress in the workplace for adult employees without diagnosed mental illness. The main effectiveness outcomes…

Islet Transplantation for the Treatment of Type 1 Diabetes - An update

December 01, 2008

| Bing Guo, Paula Corabian, Christa Harstall

The purpose of this report is to update an earlier HTA report published in 2003. This report examines the newly published clinical research evidence on the safety and efficacy/effectiveness of islet transplantation in type 1 diabetic patients who have severe hypoglycemia episodes or hyperglycemia unawareness but are without kidney failure. The main clinical efficacy/effectiveness…

The Actim™ Partus versus the TLIIQ® System as rapid response tests to aid in diagnosing preterm labour in symptomatic women

February 25, 2008

| Paula Corabian

This rapid assessment addressed a request to assess the published research evidence on how the Actim™ Partus test compares to the TliIQ® System in terms of diagnostic accuracy, clinical utility, and costs when added to preterm labour management in symptomatic women with intact membranes.

Using Fetal Fibronectin to Diagnose Pre-term Labour

January 01, 2008

| Paula Corabian, Christa Harstall

The role of rapid fetal fibronectin assay in the management of spontaneous preterm labour The objective of this report is to evaluate the added value of using fetal fibronectin (Rapid fFN for the TLi™ System, referred to here as the rapid fFN assay) to diagnose spontaneous preterm labour (PTL) in symptomatic women, which is the only fFN detection modality currently available…

Protocols For Stillbirth Investigation

October 01, 2005

| Paula Corabian, Ann Scott

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #36. The objective of this report is to identify the most appropriate investigative protocol, or component of a protocol, for determining the cause(s) of stillbirth and to identify protocols that have been recommended by health authorities and professional associations both within Canada and worldwide. Information…

Sclerotherapy for leg varicose veins

May 01, 2004

| Paula Corabian, Christa Harstall

Alberta Heritage Foundation for Medical Research (AHFMR) Information Paper #19. The objective of this report was to conduct a systematic review of the published research on the use of sclerotherapy to manage varicose veins of the legs. The intent of this paper was to answer the following questions: Is sclerotherapy effective for varicose veins of the legs and if so, is one approach…

Ovulation Induction Drug Therapy for Anovulatory Infertility Associated with Polycystic Ovary Syndrome

March 01, 2004

| Paula Corabian, Ann Scott

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #33. This report is a systematic review and critical appraisal of the evidence on the use of ovulation induction (OI) drug therapy to manage anovulatory infertility associated with polycystic ovary syndrome (PCOS) in women of reproductive age. The aim was to provide the current published scientific evidence about…

Surgical Treatments for Deep Venous Incompetence

July 01, 2003

| Ann Scott, Paula Corabian

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #32. The aim of this report was to critically appraise and synthesise the published evidence regarding the short- and long-term efficacy/effectiveness of surgical techniques for patients with deep venous incompetence, and attendant skin changes/ulceration, that is refractory to standard care. Information Specialist:…

Islet Cell Transplantation for the Treatment of Non-uremic Type 1 Diabetic Patients with Severe Hypoglycemia

April 01, 2003

| Bing Guo, Christa Harstall, Paula Corabian

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #31. This report was prepared in response to a request from Alberta Health and Wellness (AHW) for information about the use of islet cell transplantation for patients with type 1 diabetes. AHW was specifically interested in the current status of islet cell transplantation using the Edmonton protocol for a sub-population…

Accuracy and reliability of using computerized interpretation of electrocardiograms for routine examinations

January 01, 2002

| Paula Corabian

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #25. This report is a systematic review of the literature on the use of computerized electrocardiogram (ECG) interpretation for detecting heart conditions as a part of routine medical examinations in healthy adults. The aim of this report is to inform practitioners and other interested parties on the available…

Vagus Nerve Stimulation for Refractory Epilepsy

March 01, 2001

| Paula Corabian, Patricia Leggett Tait

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #24. This report has been produced in response to a request from Alberta Health and Wellness for an update on the use of vagus nerve stimulation (VNS) for refractory epilepsy. The intent was to inform health policy makers, medical practitioners, and the public on the current status of the use of VNS for refractory…

Patient Diabetes Education in the Management of Adult Type 2 Diabetes

February 01, 2001

| Paula Corabian, Christa Harstall

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #23. This report is a systematic review and critical appraisal of the literature on the use of formal outpatient diabetes education as a therapeutic tool for self-management in adult patients with type 2 diatetes. It has been prepared to provide information to the Capital Health Authority in Alberta, Canada and…

Functional diagnostic imaging in the assessment of myocardial viability - Part 1 - Overview

October 01, 1999

| Delma Cowley, Paula Corabian, David Hailey

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #16. This report has been prepared in view of the continuing interest in positron emission tomography and other functional diagnostic imaging (FDI) methods within the Alberta health care system. It also continues the work at the Alberta Heritage Foundation for Medical Research in developing approaches to assessment…

Functional diagnostic imaging in the assessment of myocardial viability - Part 2 - Details of Studies

October 01, 1999

| Delma Cowley, Paula Corabian, David Hailey

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #16. This is the second volume of an assessment of functional diagnostic imaging methods in imaging of the myocardium. Volume 1 included an overview of the assessment findings and provided comments on the place of the FDI techniques in this application. In this volume, further details are given of the assessment…

Diagnostic Tests for Vaginosis/Vaginitis

October 01, 1998

| Christa Harstall, Paula Corabian

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #12. This report has been prepared following a request from the provincial Clinical Practice Guidelines Program for information on the accuracy of diagnostic tests for the detection of bacterial vaginosis (BV), vulvovaginal candidiasis (VVC) and trichomoniasis in females of reproductive age. The intention of this…

Functional diagnostic imaging in epilepsy

August 01, 1998

| Paula Corabian, David Hailey

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #10. This report has been prepared as part of a project to assess the role of high cost functional diagnostic imaging (FDI) and related methods in routine health care. In the present paper, the potential application of four FDI methods to the management of epilepsy is considered. The assessment considered the current…

In vitro fertilization and embryo transfer as a treatment for infertility

March 01, 1997

| Paula Corabian

Alberta Heritage Foundation for Medical Research (AHFMR) HTA Report #3. The intent of this report is to inform medical practitioners and the public on the current status of in vitro fertilization and embryo transfer (IVF-ET) as a treatment for various types of infertility, and on its use and coverage in Canada. The report has been prepared because of the interest and debate regarding…

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