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Antimicrobial stewardship, procalcitonin testing, and rapid blood-culture identification to optimize sepsis care in critically ill adult patients: A quality improvement initiative

Sepsis is a leading cause of hospital mortality, particularly in the intensive care unit (ICU) , and the related financial costs to healthcare systems are substantial.  Antimicrobial use in ICUs is considerable; early, and effective antimicrobial therapy has been associated with improved sepsis outcomes. However, up to 50% of antimicrobials are sub-optimally prescribed, contributing to adverse events, increased costs, and antimicrobial resistance.  Authors of this study examined the effect of an antimicrobial stewardship program (ASP), procalcitonin testing and rapid blood-culture identification on hospital mortality in a prospective quality improvement project in critically ill septic adults. Secondarily, they reported antimicrobial guideline concordance, acceptance of ASP interventions, and antimicrobial and health-resource utilization. Institute of Health Economics Senior Economist, Dr. Charles Yan was a co-author on the study.

Publication Type: Journal Articles

Year of Publication: 2023

Topics: Epidemiology, Infection control, Pathology

Authors: Wendy Sligl, Justin Chen, Xiaoming Wang, Cheyanne Boehm, Karen Fong, Katelynn Crick, Míriam Clua, Cassidy Codan, Tanis Dingle, Daniel Gregson, Connie Prosser, Hossein Sadrzadeh, Charles Yan, Guanmin Chen, Alena Tse-Chang, Daniel Garros, Christopher Doig, David Zygun, Dawn Opgenorth, John Conly, Sean Bagshaw

Journal Title: Antimicrobial Stewardship and Healthcare Epidemiology